Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning. Initial treatment consists of appropriate airway management and attention to acid-base abnormalities. NIH Propylene glycol poisoning is marked initially by CNS depression and an elevated osmolal gap and, later, by an increased anion gap. Mechanisms of toxicity: ACS Cent Sci. Clin Toxicol (Phila). Role of tissue metabolite accumulation in the renal toxicity of diethylene glycol. Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. Diethylene glycol is toxic to humans and animals, and death can occur by renal failure. Diethylene Glycol Safety Data Sheet according to Federal Register / Vol. Route/Organism Dose Effect 2-(2-Hydroxyethoxy)ethyl acrylate. Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. 2,2'-Oxydiethanol; Special Studies. USA.gov. Use restrictions (high), Non-reproductive organ system toxicity (moderate), and Occupational hazards (high) fragrance ingredient, solvent, viscosity decreasing agent, masking, perfuming, and viscosity controlling. -> ethanol dose (IV): 10% solution in D5W as a 40% solution, loading dose 7.5mL/kg -> 1-2mL/kg/hr-> ethanol dose (PO): quarter the above dose-> dose in CRRT: double IV dose-> maintain ethanol level @ 25-40mmol/L. Approximately 50% of ingested EG is excreted unchanged by the kidneys; however, a series of oxidation reactions in the liver and kidneys metabolize the remaining EG. Fatal poisoning with diethylene glycol in an unusual setting. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. 77, No. Quality of fixed dose artemether/lumefantrine products in Jimma Zone, Ethiopia. DEG is a widely used solvent. 2019 Apr 24;5(4):589-598. doi: 10.1021/acscentsci.8b00860. Clin Toxicol (Phila). These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. His one great achievement is being the father of two amazing children. If patients are stabilized, they may then enter the final phase with various delayed neuropathies and other neurological effects, sometimes fatal. Slaughter RJ, Mason RW, Beasley DM, Vale JA, Schep LJ. Epub 2019 Mar 20. Schier JG, Hunt DR, Perala A, McMartin KE, Bartels MJ, Lewis LS, McGeehin MA, Flanders WD. Large doses and unusual circumstances are necessary for the development of propylene glycol toxicity. Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. Necessary cookies are absolutely essential for the website to function properly. In the liver, diethylene glycol is metabolized into 2-hydroxyethoxyacetic acid (aka HEAA) which is known to contribute to the renal and neurological damage that is characteristic of poisoning (Minns, 2012)(Schep et al., 2009)(Brent, 2001). Laboratory findings in clinical assessment of diethylene glycol can include an elevated osmolar gap, elevated anion gap, elevated creatinine, and acidosis [8,11,12] . January 2010 Molecular Weight. Toxicol Sci. Inhibition of metabolism of diethylene glycol prevents target organ toxicity in rats. Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. These cookies will be stored in your browser only with your consent. The difference between ethylene glycol and diethylene glycol is that an ethylene glycol molecule is an individual molecule whereas diethylene glycol molecule is formed by the combination of two ethylene glycol molecules via an ether bond. Analytical cookies are used to understand how visitors interact with the website. Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. Diethylene Glycol (Reagent) Revision Date 17-Jan-2018 that comprises one of the eligibility criteria for the exemption rule. Controversies in the Management of Functional Constipation in Children. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. Diethylene glycol is not itself acutely toxic to human tissue; however, it is readily absorbed and distributed throughout the body. The clinical effects of DEG poisoning can be divided into three stages: The first phase consists of gastrointestinal symptoms with evidence of inebriation and developing metabolic acidosis. You also have the option to opt-out of these cookies. Summary – Ethylene Glycol vs Diethylene Glycol Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. Diethylene glycol monoacrylate. He is actively involved in in using translational simulation to improve patient care and the design of processes and systems at Alfred Health. Absorption Disposition Metabolism Elimination (Dosed-Water; Gavage; Intravenous) (S0219) Completed . Toxicol Sci. Epub 2014 May 9. Clin Toxicol (Phila). Clinical features: They are based predominantly on reports following some epidemics of mass poisonings, which may underestimate toxicity. 111-46-6 - MTHSVFCYNBDYFN-UHFFFAOYSA-N - Diethylene glycol - Similar structures search, synonyms, formulas, resource links, and other chemical information. Management: Prompt use of fomepizole or ethanol is important in preventing the formation of the toxic metabolite HEAA; hemodialysis can also be critical, and assisted ventilation may be required. Based on a work at https://litfl.com. Although the mechanism of toxicity is not clearly elucidated, research suggests that the DEG metabolite, HEAA, is the major contributor to renal and neurological toxicities. Testing Status of Diethylene glycol 10993-P . The mean estimated fatal dose in an adult has been defined as approximately 1 mL/kg of pure DEG. Updated. It plays a role in how your page is seen by search engine crawlers, and how it appears in SERPs He created the ‘Critically Ill Airway’ course and teaches on numerous courses around the world. Merry Funtabulously Frivolous Friday Five 330. Despite DEG's toxicity and associated epidemics of fatal poisonings, a comprehensive review has not been published. … DEG has also been inappropriately substituted in pharmaceutical preparations for nontoxic constituents, resulting in more than a dozen epidemics of human poisoning, w… Because of its adverse effects on humans, diethylene glycol is not allowed for use in food and drugs. Researchers have implicated the chemical in multiple medication-associated mass poisonings over the years, according to Joshua G. Schier and fellow researchers from the Centers for Disease Control and Prevention. He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 04/23/2018 Revision date: 04/23/2018 Supersedes: 10/20/2015 Version: 1.2 After finishing his medical degree at the University of Auckland, he continued post-graduate training in New Zealand as well as Australia’s Northern Territory, Perth and Melbourne. 3.1O acute toxicity (oral) 4 Acute Tox. The aim of this review is to summarize all main aspects of DEG poisoning including epidemiology, toxicokinetics, mechanisms of toxicity, clinical features, toxicity of DEG, diagnosis, and management. 2019 Dec;15(4):649-652. doi: 10.1007/s12024-019-00123-4.  |  Conclusions: Diethylene glycol poisoning can also result in hepatic disease, pancreatitis, and neurologic abnormalities, which appear up to a few days after exposure [8,12]. For rats, mice and dogs the oral LD 50 was between 10000 and 27000 mg/kg body weight. 2014 Jun;52(5):470-8. doi: 10.3109/15563650.2014.914527. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings spanning back to 1937. DEG is used as a component of multiple different products including antifreeze preparations, cosmetics, lubricants, brake fluids, wallpaper strippers, heating/cooling fuel and as a plasticizer. More often, these epidemics have occurred in developing and impoverished nations where there is limited access to intensive medical care and quality control procedures are substandard. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings spanning back to 1937. These cookies do not store any personal information. CNS depression begins soon after exposure, lasting for up to 12 hours after ingestion. 2010 Sep;117(1):25-35. doi: 10.1093/toxsci/kfq167. He is also the Innovation Lead for the Australian Centre for Health Innovation at Alfred Health and Clinical Adjunct Associate Professor at Monash University. Besenhofer LM, McLaren MC, Latimer B, Bartels M, Filary MJ, Perala AW, McMartin KE. Synonyms. NLM McKenzie BA, Robles-Najar J, Duong E, Brisk P, Grover WH. drunk: automotive antifreeze, solvent, polish, paints, cosmetics, brake fluid, car wash fluid.  |  Welcome to PubChem! U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA Occupational Safety and Health Administration Belew S, Suleman S, Mohammed T, Mekonnen Y, Duguma M, Teshome H, Bayisa B, Wynendaele E, D'Hondt M, Duchateau L, De Spiegeleer B. Malar J. Furthermore, it is listed in section II, perfume and aromatic raw materials. 2011 Oct;123(2):374-83. doi: 10.1093/toxsci/kfr197. Diethylene glycol (DEG) Diethylene glycol What is it? Introduction: HHS Aim: He is on the Board of Directors for the Intensive Care Foundation and is a First Part Examiner for the College of Intensive Care Medicine. BACKGROUND Diethylene glycol (DEG) (CAS 111-46-6) is listed in the Inventory with functions as solvent, viscosity controlling and masking/perfuming. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. CASRN: 111-46-6 Formula: C4-H10-O3 Synonyms/Common Names. This category only includes cookies that ensures basic functionalities and security features of the website. 2-Propenoic acid, 2-(2-hydroxyethoxy)ethyl ester